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Title: Myelin structure is a key difference in the x-ray scattering signature between meningioma, schwannoma and glioblastoma multiforme
Contributor(s): Falzon, Gregory (author)orcid ; Pearson, Sarah Jayne (author); Murison, Robert David (author); Hall, C (author); Siu, K (author); Round, A (author); Schültke, E (author); Kaye, AH (author); Lewis, R (author)
Publication Date: 2007
DOI: 10.1088/0031-9155/52/21/014
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Abstract: Small angle x-ray scattering (SAXS) patterns of benign and malignant brain tumour tissue were examined. Independent component analysis was used to find a feature set representing the images collected. A set of coefficients was then used to describe each image, which allowed the use of the statistical technique of flexible discriminant analysis to discover a hidden order in the data set. The key difference was found to be in the intensity and spectral content of the second and fourth order myelin scattering peaks. This has clearly demonstrated that significant differences in the structure of myelin exist in the highly malignant glioblastoma multiforme as opposed to the benign: meningioma and schwannoma.
Publication Type: Journal Article
Source of Publication: Physics in Medicine and Biology, 52(21), p. 6543-6553
Publisher: Institute of Physics Publishing
Place of Publication: United Kingdom
ISSN: 1361-6560
Field of Research (FOR): 029901 Biological Physics
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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