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Title: Dynamics of intestinal metabolites and morphology in response to necrotic enteritis challenge in broiler chickens
Contributor(s): Wu, Shubiao  (author)orcid ; Rodgers, Nicholas  (author); Cui, Guimei (author); Sun, Yi (author); Choct, Mingan  (author)orcid 
Publication Date: 2016
DOI: 10.1080/03079457.2016.1140896
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Abstract: Despite the relatively small contribution to metabolizable energy that volatile fatty acids (VFAs) provide in chickens, these organic acids have been reported to play beneficial roles in the gastrointestinal tract (GIT) of birds, for example, inhibition of the growth of some pathogenic bacteria. However, information regarding the dynamics of these metabolites in the GIT of chickens is still scarce, especially under disease conditions such as necrotic enteritis (NE). Here, we investigated the dynamics of VFAs and lactic acid, and intestinal morphology in response to NE predisposing factors, that is, excessive dietary fishmeal and 'Eimeria' inoculation, and causative agent 'Clostridium' perfringens producing NetB toxin. The experiment was designed in a 2 x 2 x 2 factorial arrangement of treatments with or without: fishmeal feeding, 'Eimeria' inoculation and 'C. perfringens' challenge. The results showed that these factors significantly influenced composition and concentration of VFAs and lactic acids, pH and histomorphometry in one way or another. These changes may be important for the onset of NE or only the synergetic responses to micro environmental stress. 'Eimeria' appeared to be more important than fishmeal in predisposing birds to NE, thus the application of 'Eimeria' in NE challenge provides more consistent success in inducing the disease. The metabolic responses to various adverse factors such as excessive dietary fishmeal and 'Eimeria' infection are complex. Thus, intensive efforts are required to better understand NE so as to achieve the control of the disease in the absence of antibiotics.
Publication Type: Journal Article
Source of Publication: Avian Pathology, 45(3), p. 346-356
Publisher: Taylor & Francis
Place of Publication: Oxfordshire, United Kingdom
ISSN: 0307-9457
Field of Research (FOR): 070205 Animal Protection (Pests and Pathogens)
070204 Animal Nutrition
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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