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Title: Anatomy, Physiology and Cholinergic Modulation of Rat Entorhinal Cortex
Contributor(s): Duffield, Helen (author); Wilson, Peter (supervisor)
Conferred Date: 2008
Copyright Date: 2007
Open Access: Yes
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Abstract: This study is concerned with the microanatomy of cholinergic septohippocampal afferents in the entorhinal cortex, and with the morphology and interlaminar projections of entorhinal cortex neurons. The entorhinal cortex is known to play a critical role in memory and cognition. It occupies an important anatomical position in the medial temporal region, where it functions as the main conduit for the bidirectional flow of information between the hippocampus and higher order association areas of neocortex. The superficial layers of the entorhinal cortex give rise to hippocampal input and its deep layers receive hippocampal output. Deep to superficial interlaminar projections link hippocampal output and input fields, thus closing the corticohippocampal loop. Cholinergic modulation of the entorhinal cortex and hippocampus is important for memory function. In rodent species, it has been found that lesions of the medial septum result in profound impairment of learning and memory, and in humans, Alzheimer's disease is associated with degeneration of septohippocampal cholinergic neurons. Corticohippocampal information transfer is facilitated by oscillatory activity in entorhinal cortex layers II and V, which is modulated by septohippocampal cholinergic afferents.
Publication Type: Thesis Doctoral
Rights Statement: Copyright 2007 - Helen Duffield
HERDC Category Description: T2 Thesis - Doctorate by Research
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