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Title: Genomics Approaches to Study the Biology of Underlying Resistance to Trypanosomiasis: Some Unexpected Lessons
Contributor(s): Kemp, S J (author); Hanotte, O (author); Agaba, M (author); Noyes, H A (author); Gibson, John (author); Archibald, A (author); Rennie, C (author); Hulme, H (author); Brass, A (author)
Publication Date: 2008
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Abstract: An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following 'T. congolense' infection in both cattle and mice. The approach uses expression analysis to examine the response of both susceptible and resistant strains and a series of novel informatics tools to identify pathways which are activated as a result of challenge, and those which are differentially used by resistant and susceptible strains. Of particular interest are those pathways which simultaneously satisfy both criteria, i.e. are significantly differentially activated and contain genes within QTL regions. However, it is important to stress that it is not required that the genes within the QTL region are differentially expressed themselves.
Publication Type: Journal Article
Source of Publication: Developments in Biologicals, v.132, p. 89-92
Publisher: S Karger AG
Place of Publication: Switzerland
ISSN: 1424-6074
Field of Research (FOR): 060405 Gene Expression (incl Microarray and other genome-wide approaches)
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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