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|Title:||Relationship between stress and relapse in multiple sclerosis: part II: Direct and indirect relationships||Contributor(s):||Brown, RF (author); Tennant, CC (author); Sharrock, M (author); Hodgkinson, S (author); Dunn, SM (author); Pollard, JD (author)||Publication Date:||2006||DOI:||10.1191/1352458506ms1296oa||Handle Link:||https://hdl.handle.net/1959.11/314||Abstract:||OBJECTIVE: The aim of this two-year prospective study was to determine which factors were: (i) directly related and/or (ii) indirectly related to multiple sclerosis (MS) relapse. These factors included life-event stressors, disease, demographic, psychosocial and lifestyle factors.BACKGROUND: Relatively little attention has been paid to the role of non-clinical relapse predictors (other than stressful life-events) in MS, or factors that indirectly impact on the stress-relapse relationship.METHODS: A total of 101 consecutive participants with MS were recruited from two MS clinics in Sydney, Australia. Stressful life-events, depression, anxiety and fatigue were assessed at study-entry and at three-monthly intervals for two years. Disease, demographic, psychosocial and lifestyle factors were assessed at baseline. Patient-reported relapses were recorded and corroborated by neurologists or evaluated against accepted relapse criteria.RESULTS: MS relapse was predicted by acute stressor frequency counts, coping responses that utilized social support, and being born in Australia, but not by chronic stressors, disease, demographic, psychosocial or lifestyle factors. No factors were found to indirectly impact on the stress relapse relationship.CONCLUSIONS: The number rather than severity of stressors was most important in relation to MS relapse risk, along with coping responses that utilized social support, suggesting that MS patients should avoid situations that are likely to generate multiple stressors or which provide few avenues for social support.||Publication Type:||Journal Article||Source of Publication:||Multiple Sclerosis, 12(4), p. 465-475||Publisher:||Sage Publications Ltd||Place of Publication:||United Kingdom||ISSN:||1352-4585||Field of Research (FOR):||170106 Health, Clinical and Counselling Psychology||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 135
|Appears in Collections:||Journal Article|
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