Please use this identifier to cite or link to this item:
Title: Leptin alters the structural and functional characteristics of adipose tissue before birth
Contributor(s): Yuens, BS (author); Owens, PC (author); Muhlhausler, BS (author); Roberts, CT (author); Symonds, ME (author); Keisler, DH (author); McFarlane, JR (author)orcid ; Kauter, K (author); Evens, Y (author); McMillen, IC (author)
Publication Date: 2003
DOI: 10.1096/fj.02-0756fje
Handle Link:
Abstract: This study aimed to determine for the first time whether leptin can act to alter the structural andfunctional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline wasinfused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation(term=147±3 days). Circulating leptin concentrations were increased approximately four- tofivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion ofsmaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associatedwith a significant increase in the proportion of multilocular tissue and a significant decrease inthe proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance ofleptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was apositive correlation between the relative abundance of leptin mRNA and the proportion ofunilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher(P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstrationthat leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, andpotential thermogenic functions of fat before birth.
Publication Type: Journal Article
Source of Publication: FASEB Journal, 17(9), p. 1102-1104
Publisher: Federation Amer Soc Exp Biol
Place of Publication: Bethesda, USA
ISSN: 0892-6638
Field of Research (FOR): 111404 Reproduction
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
Statistics to Oct 2018: Visitors: 267
Views: 269
Downloads: 0
Appears in Collections:Journal Article

Files in This Item:
2 files
File Description SizeFormat 
Show full item record

Page view(s)

checked on Dec 29, 2018
Google Media

Google ScholarTM





Items in Research UNE are protected by copyright, with all rights reserved, unless otherwise indicated.