Please use this identifier to cite or link to this item: https://une.intersearch.com.au/unejspui/handle/1959.11/34
Title: Leptin alters the structural and functional characteristics of adipose tissue before birth
Contributor(s): Yuens, BS (author); Owens, PC (author); Muhlhausler, BS (author); Roberts, CT (author); Symonds, ME (author); Keisler, DH (author); McFarlane, JR (author)orcid ; Kauter, K (author); Evens, Y (author); McMillen, IC (author)
Publication Date: 2003
DOI: 10.1096/fj.02-0756fje
Handle Link: https://hdl.handle.net/1959.11/34
Abstract: This study aimed to determine for the first time whether leptin can act to alter the structural andfunctional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline wasinfused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation(term=147±3 days). Circulating leptin concentrations were increased approximately four- tofivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion ofsmaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associatedwith a significant increase in the proportion of multilocular tissue and a significant decrease inthe proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance ofleptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was apositive correlation between the relative abundance of leptin mRNA and the proportion ofunilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher(P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstrationthat leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, andpotential thermogenic functions of fat before birth.
Publication Type: Journal Article
Source of Publication: FASEB Journal, 17(9), p. 1102-1104
Publisher: Federation Amer Soc Exp Biol
Place of Publication: Bethesda, USA
ISSN: 0892-6638
Field of Research (FOR): 111404 Reproduction
Peer Reviewed: Yes
HERDC Category Description: C1 Refereed Article in a Scholarly Journal
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