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|Title:||Leptin alters the structural and functional characteristics of adipose tissue before birth||Contributor(s):||Yuens, BS (author); Owens, PC (author); Muhlhausler, BS (author); Roberts, CT (author); Symonds, ME (author); Keisler, DH (author); McFarlane, JR (author) ; Kauter, K (author); Evens, Y (author); McMillen, IC (author)||Publication Date:||2003||DOI:||10.1096/fj.02-0756fje||Handle Link:||https://hdl.handle.net/1959.11/34||Abstract:||This study aimed to determine for the first time whether leptin can act to alter the structural andfunctional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline wasinfused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation(term=147±3 days). Circulating leptin concentrations were increased approximately four- tofivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion ofsmaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associatedwith a significant increase in the proportion of multilocular tissue and a significant decrease inthe proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance ofleptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was apositive correlation between the relative abundance of leptin mRNA and the proportion ofunilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher(P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstrationthat leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, andpotential thermogenic functions of fat before birth.||Publication Type:||Journal Article||Source of Publication:||FASEB Journal, 17(9), p. 1102-1104||Publisher:||Federation Amer Soc Exp Biol||Place of Publication:||Bethesda, USA||ISSN:||0892-6638||Field of Research (FOR):||111404 Reproduction||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Statistics to Oct 2018:||Visitors: 267
|Appears in Collections:||Journal Article|
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