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|Title:||Altered lymphocyte heat shock protein 70 expression in patients with HIV disease||Contributor(s):||Agnew, L (author) ; Kelly, M (author); Howard, J (author); Jeganathan, S (author); Batterham, M (author); Ffrench, R (author); Gold, J (author); Watson, K (author)||Publication Date:||2003||Handle Link:||https://hdl.handle.net/1959.11/844||Abstract:||Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited.||Publication Type:||Journal Article||Source of Publication:||AIDS: Research Letters, 17(13), p. 1985-1988||Publisher:||Lippincott Williams & Wilkins||Place of Publication:||Philadelphia, USA||ISSN:||0269-9370||Field of Research (FOR):||110704 Cellular Immunology||Peer Reviewed:||Yes||HERDC Category Description:||C1 Refereed Article in a Scholarly Journal||Other Links:||http://www.aidsonline.com/
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